Trevor Bush

Majored in Biochemistry And Biology And Biotechnology
Worcester Polytechnic Institute, Class of 2025
From Leominster, Massachusetts

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Education

Worcester Polytechnic Institute
Francis W. Parker Charter School

Trevor in the News

Trevor Bush Named to Worcester Polytechnic Institute's Spring 2025 Dean's List

Worcester Polytechnic Institute (WPI) has announced that Trevor Bush, a member of the class of 2025 majoring in Biochemistry and Biology and Biotechnology, was named to the university's Dean's List...

June, 17 2025 - Verified by Worcester Polytechnic Institute

Trevor Bush Completes Intensive Capstone Research Project

Trevor Bush, a member of the class of 2025 majoring in Biochemistry and Biology and Biotechnology at Worcester Polytechnic Institute (WPI), recently completed a senior thesis that is required of al...

May, 29 2025 - Verified by Worcester Polytechnic Institute

Trevor Bush Receives Bachelor's Degree at Worcester Polytechnic Institute's 156th Commencement

On Friday, May 16, Trevor Bush, who majored in Biochemistry and Biology and Biotechnology, was bestowed a bachelor's degree at WPI's 156th Commencement. Nearly 1,300 undergraduate degrees were awar...

May, 27 2025 - Verified by Worcester Polytechnic Institute

Trevor Bush Named to Worcester Polytechnic Institute's Fall 2024 Dean's List

January, 30 2025 - Verified by Worcester Polytechnic Institute

Trevor Bush Completes Intensive Research Project

Trevor Bush, a member of the class of 2025 majoring in Biochemistry and Biology and Biotechnology at Worcester Polytechnic Institute (WPI), was a member of a student team that recently completed an...

May, 10 2024 - Verified by Worcester Polytechnic Institute

Student Trevor Bush of Leominster, Massachusetts Receives Honorable Mention for Prestigious Two Towers Prize at Worcester Polytechnic Institute

The Office of the Provost at Worcester Polytechnic Institute (WPI) is pleased to announce Trevor Bush of Leominster, Massachusetts, class of 2025, majoring in Biochemistry and Biology and Biotechno...

April, 29 2024 - Verified by Worcester Polytechnic Institute

Trevor Bush Named to Worcester Polytechnic Institute's Fall 2023 Dean's List

February, 01 2024 - Verified by Worcester Polytechnic Institute

Trevor Bush Named to Worcester Polytechnic Institute's Spring 2023 Dean's List

Worcester Polytechnic Institute (WPI) has announced that Trevor Bush, a member of the class of 2025 majoring in Biology and Biotechnology, was named to the university's Dean's List for academic exc...

May, 23 2023 - Verified by Worcester Polytechnic Institute

Trevor Bush Named to Worcester Polytechnic Institute's Fall 2022 Dean's List

Worcester Polytechnic Institute (WPI) has announced that Trevor Bush, a member of the class of 2025 majoring in Biology and Biotechnology (BS), was named to the university's Dean's List for academi...

January, 27 2023 - Verified by Worcester Polytechnic Institute

Trevor Bush Initiated into Omicron Delta Kappa

Trevor Bush, a native of Leominster, was recently initiated into the Worcester Polytechnic Institute Circle of Omicron Delta Kappa, the National Leadership Honor Society. The Society welcomed 1,085...

January, 13 2023 - Omicron Delta Kappa

Leominster Resident Trevor Bush Enrolled at Worcester Polytechnic Institute

Worcester Polytechnic Institute (WPI), one of the nation's first engineering and technology universities, and a global leader in project-based learning, welcomes Trevor Bush of Leominster, MA, one ...

August, 18 2021 - Verified by Worcester Polytechnic Institute

Achievements Added by Trevor

Trevor Bush was recognized for graduating

Added by Trevor

Projects + Publications

Computational Analysis of B. burgdorferi P35 Antigen to Propose Drug Targets for Inhibiting Factor H-Binding Protein

Lyme Disease, the most prevalent vector-borne illness in North America, stems from B. burgdorferi infection transmitted by ticks. Initial symptoms encompass fever, joint aches, lymph node swelling, and rash. Untreated cases progress to severe manifestations like facial palsy, arthritis, intense headaches, and brain inflammation. With an average of 476,000 cases between 2010 and 2018, Lyme disease poses a significant healthcare challenge. Borrelia burgdorferis BBA64 gene is a surface-localized lipoprotein and its protein H7C7P4 (P35 Antigen) play a crucial role in the trans-mission of B. burgdorferi. Comparing compatibility could aid in identifying antibodies specific to the P35 antigen, potentially enhancing efficacy against transmission. The tools PDB, UniProt KB, T-Coffee, InterPro, UCSF Chimera, and HDOCK were integrated for proteomic analysis of H7C7P4 and structural, sequence, and docking analysis to elucidate the P35 Antigen's characteristics and to propose a novel drug target.

December 2023 - Classwork

A methoxylated flavone from Artemisia afra kills Mycobacterium tuberculosis

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a deadly and debilitating disease globally affecting millions annually. Emerging drug-resistant Mtb strains endanger the efficacy of the current combination therapies employed to treat tuberculosis; therefore, there is an urgent need to develop novel drugs to combat this disease. Artemisia afra is used traditionally in southern Africa to treat malaria and recently has shown anti tuberculosis activity. This genus synthesizes a prodigious number of phytochemicals, many of which have demonstrated human health effects. Transcriptomic analysis revealed that A. afra exerts different effects on Mtb compared to A. annua or the well-known antimalarial artemisinin, suggesting other phytochemicals present in A. afra with unique modes of action. A biochemometric study of A. afra resulted in the isolation of a methoxylated flavone (1), which displayed considerable activity against Mtb strain mc26230. Compound 1 had an MIC of 312.5 μg/mL and yielded no viable colonies after 6 days of treatment. In addition, 1 was effective in killing hypoxic Mtb cultures, with no viable cultures after 2 days of treatment. This suggested that A. afra is a source of potentially powerful anti-Mtb phytochemicals with novel mechanisms of action.

October 2023 - Publications

Effects of Artemisinin Derivatives in Dermal Fibroblasts

Fibrosis is a pathological occurrence in most chronic inflammatory and autoimmune diseases where wound healing results in the buildup of non-functional tissue. This process involves the excessive aggregation of extracellular matrix proteins, posing a significant threat of organ failure. Unfortunately, there are few treatments for fibrosis. Most known for its antimalarial activity, artemisinin (ART), from the plant Artemisia annua L. and its derivatives artesunate (AS), artemether (AM), and dihydroartemisinin (DHA) along with A. annua tea infusions are used globally against malaria and other infectious diseases including possibly against fibrosis. The aim here was to determine morphological and extracellular matrix protein changes in fibroblasts during their transition to myofibroblasts post drug treatment. Preliminary growth and qPCR results indicated that not all artemisinin derivatives similarly affected fibroblasts, highlighting the need for further investigation.

August 2023 - Research Projects

Appreciate What Lives Beneath Your Feet: Soil Biota, the Microbes that Rule the Earth

This specific chapter delves into various factoids about the biodiversity of soil microbes—bacteria, actinomycetes, fungi, algae, protozoa and nematodes—such as their population, status, and various ecological and economic roles. Many ecosystem services are reliant on soil biota, and they have a vital role in the regulation and cycling of nutrients and the decomposition of organic matter; even so, they are often not included in environmental protections. In general, there are multiple soil conservation efforts currently in practice, such as alternate agricultural practices that reduce fertilizers, pesticides, or tillage. However, due to the expansiveness of these organisms, it is difficult to determine either the long-term effectiveness or broad usage of these methods.

March 2022 - Publications

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