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Yasmin Mann

Student at University of Delaware majoring in BIS-BSAS / Biological Sciences BS and NEU-BSAS/ Neuroscience BS, minoring in Biochemistry
Undergraduate student pursing an Honors Bachelor of Science Degree with Distinction in Biological Sciences and Neuroscience, with a concentration in Cell and Molecular Biology and Genetics, and a minor in Biochemistry with plans to obtain a PhD in Immunology after graduation. Involved in undergraduate research with a focus on cancer. Currently working with Dr. Kenneth van Golen and Dr. Carlton Cooper looking at prostate cancer metastasis to bone.
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UD student Yasmin Mann conducts summer research

This summer, Yasmin Mann was one of more than 400 UD undergraduate students who worked on a range of research projects in disciplines all across the university as well as in the community. Over th...

October, 21 2019 - Verified by University of Delaware
Yasmin Mann has been named to the University of Delaware's Dean's List for the Spring 2019 semester

Yasmin Mann has been named to the University of Delaware's Dean's List for the Spring 2019 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time and ...

June, 19 2019 - Verified by University of Delaware
Yasmin Mann Inducted into The Honor Society of Phi Kappa Phi

Yasmin Mann of Middletown, Delaware, was recently initiated into The Honor Society of Phi Kappa Phi, the nation's oldest and most selective all-discipline collegiate honor society. Mann is pursui...

February, 04 2019 - Verified by The Honor Society of Phi Kappa Phi
Yasmin Mann has been named to the University of Delaware's Dean's List for the Fall 2018 semester

Yasmin Mann has been named to the University of Delaware's Dean's List for the Fall 2018 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time and ea...

January, 28 2019 - Verified by University of Delaware
Yasmin Mann has been named to the University of Delaware's Dean's List for the Spring 2018 semester

Yasmin Mann has been named to the University of Delaware's Dean's List for the Spring 2018 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time and ...

June, 14 2018 - Verified by University of Delaware
Yasmin Mann has been named to the University of Delaware's Dean's List for the Fall 2017 semester

Yasmin Mann has been named to the University of Delaware's Dean's List for the Fall 2017 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time and ea...

January, 19 2018 - Verified by University of Delaware
Yasmin Mann has been named to the University of Delaware's Dean's List for the Spring 2017 semester.

Yasmin Mann has been named to the University of Delaware's Dean's List for the Spring 2017 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time and ...

June, 15 2017 - Verified by University of Delaware
Yasmin Mann has been named to the University of Delaware's Dean's List for the Fall 2016 semester.

Yasmin Mann has been named to the University of Delaware's Dean's List for the Fall 2016 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time and ea...

January, 26 2017 - Verified by University of Delaware
Yasmin Mann was recognized for an academic accomplishment
Fall 2016 - Spring 2019 - Added by Yasmin
Yasmin Mann was recognized for winning a scholarship
Barry Goldwater 2019 Scholar
Added by Yasmin
Beta Beta Beta
Assistive Medical Technologies Club
Health Equity Club
Undergraduate Researcher at University of Delaware Summer Scholars

The rate of prostate cancer metastasis is significantly greater in the African American male population. This may be due to the high levels of oxidative stress (OS) also experienced by this particular group. I hypothesized that high levels of OS cause an increased expression of cell adhesion molecules (CAMs) on human bone marrow endothelial cells (HBMECs), allowing for greater prostate cancer cell (PCa) attachment and metastasis. To test this, I induced OS in HBMECs by treating them with the chemical SIN-1 and then co-cultured labeled PCas with the treated HBMECs. Cell attachment was measured via flow cytometry, which was found to be increased in the treated cell condition.

June 2019 - August 2019
Research Intern at Fox Chase Cancer Center

My project looked at the effects of anti-cancer drugs on primary cilia-associated PDGFR-alpha signaling. Primary cilia house many receptors that are important for the regulation of normal cell signaling. In cancer, ciliation is often abnormal as is cell signaling. I wanted to see if there is a relationship between cell signaling and ciliation state. My lab previously found that a number of clinically available anti-cancer drugs do have an effect on ciliation, either promoting their growth or removal. I hypothesized that cells treated with drugs that promoted ciliation would have higher levels of PDGFRa signaling while cilia destabilizing drugs would reduce signaling. I cultured NIH cells, serum starved them to induce ciliation, and treated them with the drugs of interest. I then analyzed ciliation state through immunofluorescence, and PDGFRa signaling through Western blotting and immunofluorescence. I found that by inhibiting ciliation, there is a reduction in PDGRa signaling.

June 2018 - August 2018
Undergraduate Research Intern at AI DuPont Children's Hospital

Adoptive T-cell therapy is a novel cancer treatment where a patient's T-cells are genetically modified to express a chimeric antigen receptor (CAR) that helps T-cells target cancer cells. I investigated whether tuning the binding affinity of the receptor improved the targeting of breast cancer cells expressing Her2. To do this, I made 3 DNA constructs that coded for a Her2 recognizing CAR, which vary in binding affinity, using site directed mutagenesis, KLD reaction and PCR. I then transformed E.coli to mass produce my constructs and checked the collected plasmids via restriction enzyme digest, gel electrophoresis and sequencing. Primary mouse T-cells were then transfected using retroviral vectors and found to kill Her2 positive cells from preliminary killing assays.

June 2017 - August 2017
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