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Melodie Melbouci

Majoring in Biological Sciences, Minoring in Equine Science, Medical Diagnostics
University of Delaware, Class of 2018
From Wilmington, DE
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University of Delaware
University of North Carolina at Chapel Hill
Conrad Schools of Science

Melodie Melbouci has been named to the University of Delaware's Dean's List for the Spring 2018 semester

Melodie Melbouci has been named to the University of Delaware's Dean's List for the Spring 2018 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time...

June, 14 2018 - University of Delaware
Melodie Melbouci has been named to the University of Delaware's Dean's List for the Fall 2017 semester

Melodie Melbouci has been named to the University of Delaware's Dean's List for the Fall 2017 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time a...

January, 19 2018 - University of Delaware
Melodie Melbouci has been named to the University of Delaware's Dean's List for the Spring 2017 semester.

Melodie Melbouci has been named to the University of Delaware's Dean's List for the Spring 2017 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time...

June, 15 2017 - University of Delaware
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Melodie Melbouci participates in UDance at UD

Melodie Melbouci of Wilmington, DE, joined the fight against childhood cancer as a Moraler with UDance at the University of Delaware. UDance is the university's largest student-run philanthropy ben...

April, 04 2017 - University of Delaware
Melodie Melbouci has been named to the University of Delaware's Dean's List for the Fall 2016 semester.

Melodie Melbouci has been named to the University of Delaware's Dean's List for the Fall 2016 semester. To meet eligibility requirements for the Dean's List, a student must be enrolled full-time a...

January, 26 2017 - University of Delaware
Melodie Melbouci named to Dean's List for Spring 2016

Melodie Melbouci of Wilmington, DE, has been named to University of Delaware's Dean's List for the Spring 2016 semester. The Dean's List, an honor conferred at the end of the fall and spring semes...

June, 30 2016 - University of Delaware
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Melodie Melbouci has been named to the University of Delaware's Dean's List for the 2015 fall semester

Melodie Melbouci from Wilmington, DE has been named to the University of Delaware's Dean's List for the 2015 fall semester. To meet eligibility requirements for the Dean's List, a student must be ...

January, 20 2016 - University of Delaware
Melodie Melbouci has been named to the University of Delaware's Dean's List for the 2015 spring semester

Melodie Melbouci from Wilmington, DE has been named to the University of Delaware's Dean's List for the 2015 spring semester. To meet eligibility requirements for the Dean's List, a student must b...

July, 15 2015 - University of Delaware
Beta Beta Beta
I am a member and the Marketing Coordinator (2017-2018) for Beta Beta Beta Biological Honors Society. Im in charge with handling our social media accounts and creating and ordering all of our merchandise.
Fall 2016 - Spring 2018 - University of Delaware
Added by Melodie
Equestrian Club
We compete every weekend against multiple colleges as a part of the IHSA!
University of Delaware
Added by Melodie
Medical Imaging Volunteer at A.I. duPont Hospital for Children| Nemours

I wipe down tables and aprons between usages, and escort patients to and from their rooms to x-ray.

January 2017 - Present
Research Student at A.I. duPont Hospital for Children| Nemours

Besides taking part in minor experiments in the skeletal dysplasia lab, I also author manuscripts pertaining to our area of research, the lysosomal storage disorders known by the name of Mucopolysaccharidoses (MPS).

April 2016 - Present
Barn and TRAC Volunteer at Carousel Park Equestrian Center
I help out around the barn doing a variety of chores. I also assist the instructors who are a part of the therapeutic program with their students.
June 2013 - Present
Growth impairment in mucopolysaccharidoses
Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders that affect regulation of glycosaminoglycan (GAG) processing. In MPS, the lysosomes cannot efficiently break down GAGs, and the specific GAGs accumulated depend on the type of MPS. The level of impairment of breakdown varies between patients, making this one of the many factors that lead to a range of clinical presentations even in the same type of MPS. These clinical presentations usually involve skeletal dysplasia, in which the most common feature is bone growth impairment and successive short stature. Growth impairment occurs due to the deposition and retention of GAGs in bone and cartilage. The accumulation of GAGs in these tissues leads to progressive damage in cartilage that in turn reduces bone growth by destruction of the growth plate, incomplete ossification, and imbalance of growth. Imbalance of growth leads to various skeletal abnormalities including disproportionate dwarfism with short neck and trunk, prominent forehead, rigidity of joints, tracheal obstruction, kyphoscoliosis, pectus carinatum, platyspondyly, round-shaped vertebral bodies or beaking sign, underdeveloped acetabula, wide flared iliac, coxa valgus, flattered capital femoral epiphyses, and genu valgum. If left untreated, skeletal abnormalities including growth impairment result in a significant impact on these patients' quality of life and activity of daily living, leading to high morbidity and severe handicap. This review focuses on growth impairment in untreated patients with MPS. We comprehensively describe the growth abnormalities through height, weight, growth velocity, and BMI in each type of MPS and compare the status of growth with healthy age-matched controls. The timing, the degree, and the difference in growth impairment of each MPS are highlighted to understand the natural course of growth and to evaluate future therapeutic efficacy.
Publications
Morquio Syndrome (Mucopolysaccharidosis Type IV)
Morquio syndrome (mucopolysaccharidosis type IV [MPS IV]) is a rare lysosomal storage disease (LSD) that is inherited in an autosomal-recessive fashion. Morquio syndrome is classified into two types, Morquio A syndrome and Morquio B syndrome, based on a deficiency of different lysosomal enzymes—N-acetylgalactosamine-6-sulfate sulfatase (GALNS) and β-galactosidase, respectively. GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS), and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, while β-galactosidase deficiency induces the accumulation of only KS in those tissues.
Publications

Dean's List

Melodie was awarded this badge for 7 achievements. Click on the stories below to view them.

  • Melodie Melbouci has been named to the University of Delaware's Dean's List for the Spring 2018 semester
  • Melodie Melbouci has been named to the University of Delaware's Dean's List for the Fall 2017 semester
  • Melodie Melbouci has been named to the University of Delaware's Dean's List for the Spring 2017 semester.
  • Melodie Melbouci has been named to the University of Delaware's Dean's List for the Fall 2016 semester.
  • Melodie Melbouci named to Dean's List for Spring 2016
  • Melodie Melbouci has been named to the University of Delaware's Dean's List for the 2015 fall semester
  • Melodie Melbouci has been named to the University of Delaware's Dean's List for the 2015 spring semester
Dean's List 7 Volunteer

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